Alberto Marsico was born in Turin in 1966 and started out as a pianist and keyboardist before a single week changed the direction of his career. In 1994 he attended a workshop in Genoa taught by Hammond organ legends Brother Jack McDuff and Shirley Scott, and switched to the Hammond B3 exclusively from that point on. McDuff was impressed enough by the young Italian that he recorded a tune Marsico wrote for him, "Jack-Pot," making it the title track of his own 1995 Red Records album Jack-Pot, cut with Bruno Marini, Massimo Faraò, Piero Odorici and Bobby Durham. Marsico does not play on that record himself; the connection is the dedication and the tune, not a shared credit, and it is the documented anchor of his relationship with McDuff.

That same year, Marsico's own debut as a leader, Hammond Blood (1994, with baritone saxophonist Bruno Marini and drummer Maurizio Borgia), is described by specialist sources as the first organ-trio album recorded in Italy. He built quickly on it: a 1996 tour of Spain and Portugal with Slovenian drummer Zlatko Kaučič, a month in the San Francisco Bay Area in 1998 recording Hiding in Plain Sight and performing with guitarist and singer Anthony Paule, and a run of European organ-trio and quartet records under his own name and with German, Czech and Slovenian rhythm sections, including Stop It! (1998, with guitarist Lorenzo Petrocca), Them That's Got (1998), and Trio '03 (2002, with Czech guitarist Roman Pokorný and drummer Pavel Zbořil).

His catalogue since has mixed his own organ-trio and quartet leader dates (Organ Logistics, 2004; Rock Candy, 2005, with trombonist Mauro Ottolini and trumpeter Davide Ghidoni; Four Now, 2011, with saxophonist Rob Sudduth) with notable co-billed records: Jazz-Blues Brothers (2014, Verve Records/Universal Music Group), a full-length pairing with Singapore pianist Jeremy Monteiro that the two put together after meeting on tour and Marsico helping Monteiro track down a Hammond B3 in Singapore, and More of Les (2020, Organic Music), a trio session with pianist Dado Moroni. He has also recorded internationally as a sideman, including sessions in Los Angeles with blues guitarist Alex Schultz (Think About It, 2004, Severn Records) and, in 2005, an invitation from Beatles Fan Club Italia to record an organ solo on "Can't Buy Me Love" at Abbey Road Studio 2 in London for the club's thirtieth-anniversary commemorative CD.

Since 2013 his main working group outside his own name has been trumpeter Fabrizio Bosso's Spiritual Trio, an organ-trio project built around gospel and spiritual repertoire, with drummer Alessandro Minetto completing the lineup: Purple (2013, Verve Records), Spiritual Live (2016, Casa del Jazz), Someday (2019, Warner Music Italy, with guest vocalist Mario Biondi), and Welcome Back (2025, Warner Music Italy). In 1998, on the Alessandro Di Puccio Jazz Trio's Alkaline (Splasc(h) Records), he recorded alongside vocalist Tiziana Ghiglioni.

Marsico also teaches and organizes: in 2008 he ran "We Love Jazz," a European jazz seminar whose faculty included Benny Golson, Jimmy Cobb, Buster Williams, Joey DeFrancesco and George Cables, drawing 104 international students; since 2022 he has organized Piemonte Blues Stop, a week-long international blues camp in his home town of Castagnole Piemonte whose teaching staff has included Duke Robillard, Alex Schultz, Mudcat Ward and Sugar Ray Norcia. He was also invited onto Piero Angela's science program Superquark as an expert on the Hammond organ. He remains active, with Believe (2023, a duo record with German vocalist Sonja Priehn) and Welcome Back (2025) among his most recent credits.

Marsico's playing sits inside the classic American organ-trio lineage running through Jimmy Smith and Jack McDuff, the two names he cites as his direct entry point into the instrument. By his own description, his work spans "jazz, soul, blues, funk and gospel," and his stated strength is accompanying singers: he built his reputation as much backing vocalists like Anthony Paule, Sonja Priehn and, on the Fabrizio Bosso Spiritual Trio records, Mario Biondi, as leading his own instrumental dates. The left-hand bass-line technique associated with the Hammond B3 tradition, playing the bass part on the organ's lower manual and pedals rather than using a separate bassist, is central to how he works as a one-person rhythm section in the trio format he has returned to across three decades.

His catalogue moves between two poles: small, self-led organ-trio and quartet dates rooted in soul jazz and blues (Hammond Blood, Organ Logistics, Rock Candy), and gospel-and-spirituals repertoire built specifically around the Fabrizio Bosso Spiritual Trio. The Jazz-Blues Brothers project with Jeremy Monteiro leans further into blues and funk, closer to the soul-jazz combo tradition than to a straight-ahead jazz organ trio. Across all of it, the format stays constant: organ, a horn or guitar voice, and drums, with Marsico's own instrument carrying the harmonic and rhythmic foundation.